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KMID : 0614619920240061368
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Korean Journal of Gastroenterology
1992 Volume.24 No. 6 p.1368 ~ p.1375
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Experimental Studies on Ligation of the Draining Vein in the Remnant Liver during Hepatectomy
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왕희정
전현수/서연림/박성섭/이혁상
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Abstract
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There has been a recent upsurge of systematic limited resection for hepatocellular carcinoma in patients with compromised functional reserve of the liver due to coexistence of chronic liver disease. The ultimate goal of this type of resection is
to
sae
marginal amount of noncancerous hepatic mass while radically removing the cancerous tissues. When the tumor is located in close proximity ot right hepatic vein, i. e. segment VII or VIII. it often becomes necessary to remove the vein along with
the
tumor. The issue here is the fate of segment VI without it major draining vein.
In the experimental study, the rats wee divided into two groups: Group-I (GP-I) had only hepatectomy and Group-II (Gp-II) had ligation of one hepatic vein in addition to hepatectomy. The parencheyma without draiing veins revealed severe
congestion
and
necrosis, and transaminase in Gr-II rose significantly higher than Cr-I soon operation. The hepatic volume of the vein-ligated region decreased considerablely on the 7th postoperative day. The degree of hepatic regeneration had bee measured by
the
proliferative index using flow cytometry. DNA synthesis was delayed and depressed in the insulted parenchyma. Experimental results suggest that the vein-ligated region cannot be expected to contribute significantly to postoperative liver function
at
least in the early postoperative period, and hepatic farlure may ensue in the marginal cirrhotic liver.
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KEYWORD
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